Edit: Due to the fact that this article is old, the installation instructions may not work anymore. In order to successfully install the latest version of Wine, please access the wine tag and open the latest article (the one on top).

The latest installation instructions for Wine
Hello Linux Geeksters. As you may know, Wine 1.6 stable has been released recently, after many RC versions. It comes with a huge number of bugfixes. To get a full list, see the official announcement.
In this article I will show you how to install Wine 1.6 on Fedora 19, Fedora 18, Fedora 17 and CentOS 6. Follow this instructions for a successful installation:
Install the needed dependencies:
$ sudo yum -y groupinstall 'Development Tools'
$ sudo yum -y install libX11-devel freetype-devel
Download the Wine 1.6 archive, extract it and cd into it:
$ wget -c http://garr.dl.sourceforge.net/project/wine/Source/wine-1.6.tar.bz2
$ tar -xjvf wine-1.6.tar.bz2
$ cd wine-1.6/
Install Wine, on 32 bit systems:
While on 32 ./tools/wineinstall compiles in background the package and does the needed operations for the installation to succeed, on 64 bit systems we have to do it by hand, in order to add the –enable-win64 argument for ./configure
$ ./tools/wineinstall
Install Wine, on 64 bit systems:
$ $ ./configure --enable-win64
$ make
$ sudo make install
This is everything. Enjoy. Related reading: How to install Wine 1.6 on Ubuntu and Linux Mint.