Edit: Due to the fact that this article is old, the installation instructions may not work anymore. In order to successfully install the latest version of Wine, please access the wine tag and open the latest article (the one on top).

The latest installation instructions for Wine
Wine is the most popular application for running Windows software on Linux systems.
In this article I will show you how to install WineHQ 1.5.27 on Fedora 18/17/16, CentOS 6.4/6.3/6.2/6.1/6 and RHEL 6.4/6.3/6.2/6.1/6.
Let’s start. Follow this guide exactly for a successful installation:
Installing Package Dependencies:
1. Packages such as gcc,flex or bison or libX11-devel are needed. So, do this, in your terminal:
$ sudo yum -y groupinstall 'Development Tools'
$ sudo yum -y install libX11-devel freetype-devel
2. Download the wine tarball:
$ wget http://garr.dl.sourceforge.net/project/wine/Source/wine-1.5.27.tar.bz2
3. Extract the archive and cd into it:
$ tar -xvf wine-1.5.27.tar.bz2
$ cd wine-1.5.27
4. Install wine:
$ ./tools/wineinstall
This is everything. Enjoy.